Deep Brain Stimulation: A Paradigm Shifting Approach to Treat Parkinson's Disease
نویسندگان
چکیده
منابع مشابه
Deep Brain Stimulation: A Paradigm Shifting Approach to Treat Parkinson's Disease
Parkinson disease (PD) is a chronic and progressive movement disorder classically characterized by slowed voluntary movements, resting tremor, muscle rigidity, and impaired gait and balance. Medical treatment is highly successful early on, though the majority of people experience significant complications in later stages. In advanced PD, when medications no longer adequately control motor sympt...
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OBJECTIVE Reduced verbal fluency (VF) has been reported in patients with Parkinson's disease (PD), especially those treated by Deep Brain Stimulation of the subthalamic nucleus (STN DBS). To delineate the nature of this dysfunction we aimed at identifying the particular VF-related operations modified by STN DBS. METHOD Eleven PD patients performed VF tasks in their STN DBS ON and OFF conditio...
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We propose a novel, closed-loop approach to tuning deep brain stimulation (DBS) for Parkinson's disease (PD). The approach, termed Phasic Burst Stimulation (PhaBS), applies a burst of stimulus pulses over a range of phases predicted to disrupt pathological oscillations seen in PD. Stimulation parameters are optimized based on phase response curves (PRCs), which would be measured from each patie...
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The use of deep brain stimulation in psychiatric disorders has received great interest owing to the small risk of the operation, the reversible nature of the technique, and the possibility of optimizing treatment postoperatively. Currently deep brain stimulation in psychiatry is investigated for obsessive-compulsive disorder, Gilles de la Tourette’s syndrome and major depression. This presentat...
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criteria exist for a given disorder, then surely it is unethical to categorically exclude children and adolescent patients from receiving the only treatment available that could dramatically increase their quality of life. Experts that oppose the use of DBS for pediatric TS (Mink et al., 2006; Porta et al., 2009) defend their position based upon the nature of childhood TS. According to a recent...
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ژورنال
عنوان ژورنال: Frontiers in Neuroscience
سال: 2016
ISSN: 1662-453X
DOI: 10.3389/fnins.2016.00173